2. Academic Validation
  3. Immune Regulation and Antitumor Effect of TIM-1

Immune Regulation and Antitumor Effect of TIM-1

  • J Immunol Res. 2016:2016:8605134. doi: 10.1155/2016/8605134.
Peng Du 1,  Ruihua Xiong 2,  Xiaodong Li 3,  Jingting Jiang 3
Affiliations

Affiliations

  • 1 Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China; The Second People's Hospital of Gansu Province, Lanzhou, Gansu 730000, China.
  • 2 Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China; Department of Oncology, The 181st Hospital of PLA, Guilin, Guangxi 541002, China.
  • 3 Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China.
PMID: 27413764 DOI: 10.1155/2016/8605134
Abstract

T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the Mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.

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