2. Academic Validation
  3. Mitochondria-Targeted Plastoquinone Antioxidant SkQR1 Has Positive Effect on Memory of Rats

Mitochondria-Targeted Plastoquinone Antioxidant SkQR1 Has Positive Effect on Memory of Rats

  • Biochemistry (Mosc). 2015 May;80(5):592-5. doi: 10.1134/S0006297915050119.
E V Stelmashook 1,  A V Stavrovskaya,  N G Yamshchikova,  A S Ol'shanskii,  N A Kapay,  O V Popova,  L G Khaspekov,  V G Skrebitsky,  N K Isaev
Affiliations

Affiliation

  • 1 Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, 125367, Russia. estelmash@mail.ru.
PMID: 26071778 DOI: 10.1134/S0006297915050119
Abstract

A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 µmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice significantly increases the synaptic transmission efficiency of the pyramidal neurons of the CA1 field. The findings indicate that SkQR1 has a positive effect on memory processes.

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