2. Academic Validation
  3. Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains

Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains

  • J Antibiot (Tokyo). 2015 Sep;68(9):573-8. doi: 10.1038/ja.2015.28.
Kenichi Nonaka 1 2,  Masato Iwatsuki 1 2,  Syunsuke Horiuchi 1,  Kazuro Shiomi 1 2,  Satoshi Ōmura 1,  Rokuro Masuma 1 2
Affiliations

Affiliations

  • 1 Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
  • 2 Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
PMID: 25805070 DOI: 10.1038/ja.2015.28
Abstract

While isolating Fungal strains from soil samples, two strains, Talaromyces siamensis FKA-61 and Phomopsis sp. FKA-62, were found to produce a black pigment near the boundary with an adjoining colony on agar plates. Moreover, strain FKA-61 inhibited the growth of strain FKA-62. Co-culture of T. siamensis FKA-61 with Phomopsis sp. FKA-62 resulted in the production of an Antifungal agent, BE-31405, which proved active against Phomopsis sp. FKA-62. We screened for Fungal genera that have the ability to induce production of Antifungal BE-31405. Surprisingly, production of BE-31405 was induced only by co-culturing T. siamensis FKA-61 with a variety of BE-31405-sensitive Fungal strains but never with BE-31405-insensitive strains. This is the first report of the induced production of a specific Antibiotic active against antibiotic-sensitive Fungal strains by co-culturing with them.

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