2. Academic Validation
  3. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species

In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species

  • Rev Soc Bras Med Trop. 2014 Mar-Apr;47(2):247-50. doi: 10.1590/0037-8682-0008-2013.
Graziela Teixeira de Oliveira 1,  Jaqueline Maria Siqueira Ferreira 1,  Luiz Henrique Rosa 2,  Ezequias Pessoa de Siqueira 3,  Susana Johann 2,  Luciana Alves Rodrigues dos Santos Lima 1
Affiliations

Affiliations

  • 1 Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei, Divinópolis, MG.
  • 2 Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BRAZIL.
  • 3 Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, BRAZIL.
PMID: 24861304 DOI: 10.1590/0037-8682-0008-2013
Abstract

Introduction: There are few studies reporting the Antifungal activities of Lippia alba extracts.

Methods: A broth microdilution assay was used to evaluate the Antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by gas chromatography-mass spectrometry.

Results: The butanol fraction showed the highest activity against Candida glabrata. The fraction also acted synergistically with itraconazole and fluconazole against C. glabrata. The dominant compounds in the butanol fraction were 2,2,5-trimethyl-3,4-hexanedione, 3,5-dimethyl-4-octanone and hexadecane.

Conclusions: The butanol fraction may be a good candidate in the search for new drugs from natural products with Antifungal activity.

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