2. Academic Validation
  3. 6-Oxo and 6-thio purine analogs as antimycobacterial agents

6-Oxo and 6-thio purine analogs as antimycobacterial agents

  • Bioorg Med Chem. 2013 Apr 1;21(7):1685-95. doi: 10.1016/j.bmc.2013.01.054.
Ashish K Pathak 1,  Vibha Pathak,  Lainne E Seitz,  William J Suling,  Robert C Reynolds
Affiliations

Affiliation

  • 1 Drug Discovery Division, Southern Research Institute, 2000 9th Avenue South, Birmingham, AL 35205, USA. pathaka@southernresearch.org
PMID: 23434367 DOI: 10.1016/j.bmc.2013.01.054
Abstract

6-Oxo and 6-thio analogs of purine were prepared based on the initial activity screening of a small, diverse purine library against Mycobacterium tuberculosis (Mtb). Certain 6-oxo and 6-thio-substituted purine analogs described herein showed moderate to good inhibitory activity. N(9)-substitution apparently enhances the anti-mycobacterial activity in the purine series described herein. Several 2-amino and 2-chloro purine analogs were also synthesized that showed moderate inhibitory activity against Mtb.

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