2. Academic Validation
  3. An unprecedented biogenetic-type chemical synthesis of 1(15-->11) abeotaxanes from normal taxanes

An unprecedented biogenetic-type chemical synthesis of 1(15-->11) abeotaxanes from normal taxanes

  • J Nat Prod. 2010 Apr 23;73(4):747-50. doi: 10.1021/np900722j.
T Narender 1,  K Papi Reddy,  V K Singh,  K Rajendar,  J Sarkar
Affiliations

Affiliation

  • 1 Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow-226 001, U.P., India. t_narendra@cdri.res.in
PMID: 20302348 DOI: 10.1021/np900722j
Abstract

A one-pot chemical process using BF(3).Et(2)O for the synthesis of a new class of 1(15-->11) abeotaxanes from normal taxanes has been developed. The chemical structures of rearranged 1(15-->11) abeotaxane were established by extensive 2D NMR spectroscopic data.

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