2. Academic Validation
  3. Chantriolide C, a new withanolide glucoside and a new spirostanol saponin from the rhizomes of Tacca chantrieri

Chantriolide C, a new withanolide glucoside and a new spirostanol saponin from the rhizomes of Tacca chantrieri

  • Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1126-8. doi: 10.1248/cpb.57.1126.
Lin Zhang 1,  Jiang-Yun Liu,  Li-Zhen Xu,  Shi-Lin Yang
Affiliations

Affiliation

  • 1 Zhejiang Provincial Key Laboratory Chinese Medicine Screening, Exploitation & Medicinal Effectiveness Appraise for Cardio-Cerebral Vascular & Nervous System, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China. zxxtjk@gmail.com
PMID: 19801872 DOI: 10.1248/cpb.57.1126
Abstract

A new withanolide, chantriolide C (1) and a new spirostanol saponin, chantrieroside A (2) were isolated from the rhizomes of Tacca chantrieri, together with another five known steroidal compounds. Their structures were established as (22R)-1alpha,12alpha-diacetoxy-2alpha,3alpha;6alpha,7alpha-diepoxy-27-[(beta-D-glucopyranosyl)oxy]-5alpha-hydroxywith-24-enolide (1) and (25R)-spirost-5-en-3-yl-O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->3)]-beta-D-glucopyranoside (2). The structures of the new saponins were determined by detailed analysis of their 1 dimensional (1D) and 2D NMR spectra, and chemical evidences.

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