2. Academic Validation
  3. Biotransformation of methyl cholate by Aspergillus niger

Biotransformation of methyl cholate by Aspergillus niger

  • Steroids. 2009 Apr-May;74(4-5):483-6. doi: 10.1016/j.steroids.2009.01.002.
Amal Al-Aboudi 1,  Mohammad Y Mohammad,  Salim Haddad,  Rawhi Al-Far,  M Iqbal Choudhary,  Atta-Ur-Rahman
Affiliations

Affiliation

  • 1 Chemistry Department, University of Jordan, 1194 Amman, Jordan. alaboudi@ju.edu.jo
PMID: 19428436 DOI: 10.1016/j.steroids.2009.01.002
Abstract

Biotransformation of methyl cholate using Aspergillus niger was investigated. This led to the isolation of two derivatives: methyl 3alpha,7alpha,12alpha,15beta-tetrahydroxy-5beta-cholan-24-oate identified as a new compound, and a known compound methyl 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate. The structure elucidation of the new compound was achieved using 1D and 2D NMR, MS and X-ray diffraction.

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