2. Academic Validation
  3. Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound

Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound

  • Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3. doi: 10.1016/j.bmcl.2007.12.044.
Harinath Chakrapani 1,  Michael M Goodblatt,  Vidya Udupi,  Swati Malaviya,  Paul J Shami,  Larry K Keefer,  Joseph E Saavedra
Affiliations

Affiliation

  • 1 Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, PO Box B, Frederick, MD 21702, USA. chakrah@ncifcrf.gov
PMID: 18178089 DOI: 10.1016/j.bmcl.2007.12.044
Abstract

Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified.

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