2. Academic Validation
  3. Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)

  • J Med Chem. 2007 Nov 29;50(24):5890-3. doi: 10.1021/jm7010595.
Jun Li 1,  Stephanie Y Chen,  James J Li,  Haixia Wang,  Andres S Hernandez,  Shiwei Tao,  Christa M Musial,  Fucheng Qu,  Stephen Swartz,  Sam T Chao,  Neil Flynn,  Brian J Murphy,  Dorothy A Slusarchyk,  Ramakrishna Seethala,  Mujing Yan,  Paul Sleph,  Gary Grover,  Mark A Smith,  Blake Beehler,  Leah Giupponi,  Kenneth E Dickinson,  Hongjian Zhang,  William G Humphreys,  Bharat P Patel,  Mark Schwinden,  Terry Stouch,  Peter T W Cheng,  Scott A Biller,  William R Ewing,  David Gordon,  Jeffrey A Robl,  Joseph A Tino
Affiliations

Affiliation

  • 1 Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 5400, Princeton, NJ 08543, USA. jun.li@bms.com
PMID: 17973363 DOI: 10.1021/jm7010595
Abstract

A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-119125
    GHS-R Agonist