2. Academic Validation
  3. Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity

Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity

  • Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. doi: 10.1016/j.bmc.2007.07.054.
Tae Chul Moon 1,  Zhejiu Quan,  Jeongsoo Kim,  Hyun Pyo Kim,  Ichiro Kudo,  Makodo Murakami,  Haeil Park,  Hyeun Wook Chang
Affiliations

Affiliation

  • 1 College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
PMID: 17826099 DOI: 10.1016/j.bmc.2007.07.054
Abstract

Several prototypes of C-C Biflavones (a-f) were synthesized and evaluated their inhibitory activity against Phospholipase A(2)s (PLA(2)s) activity. The synthetic C-C Biflavones (a-f) showed rather different inhibitory activity against various PLA(2)s. Most synthetic C-C biflavonoids exhibited potent and broad inhibitory activity against various sPLA(2)s and cPLA(2) tested regardless of their structural array. In particular, of natural and synthetic biflavonoids tested, the synthetic C-C biflavonoid (d) only showed inhibitory activity against sPLA(2) X. None of the natural and synthetic biflavonoids tested showed inhibitory activity against sPLA(2) IB. Further chemical modification of these basic structures will be carried out in order to investigate the synthetic C-C Biflavones which possess more selective inhibitory activity against isozymes of PLA(2).

Figures