2. Academic Validation
  3. Sultam thiourea inhibition of West Nile virus

Sultam thiourea inhibition of West Nile virus

  • Antimicrob Agents Chemother. 2007 Jul;51(7):2642-5. doi: 10.1128/AAC.00007-07.
Eric Barklis 1,  Amelia Still,  Mohammad I Sabri,  Alec J Hirsch,  Janko Nikolich-Zugich,  James Brien,  Tenzin Choesang Dhenub,  Isabel Scholz,  Ayna Alfadhli
Affiliations

Affiliation

  • 1 Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health & Sciences University, Mail Code L220, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. barklis@ohsu.edu
PMID: 17452483 DOI: 10.1128/AAC.00007-07
Abstract

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 microM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

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