2. Academic Validation
  3. Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr

Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr

  • Bioorg Med Chem. 2007 Jan 15;15(2):988-96. doi: 10.1016/j.bmc.2006.10.034.
Yi-Nan Zhang 1,  Xiang-Gen Zhong,  Zong-Ping Zheng,  Xu-Dong Hu,  Jian-Ping Zuo,  Li-Hong Hu
Affiliations

Affiliation

  • 1 Shanghai Research Center for Modernization of Traditional Chinese Medicine and First Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
PMID: 17081761 DOI: 10.1016/j.bmc.2006.10.034
Abstract

Three new Alkaloids (1-3) and twenty-one known compounds were isolated from the stem of Fissistigma oldhamii (Hemsl.) Merr. which was the ruler herb in an approved Traditional Chinese herbal formula used for treatment of rheumatoid arthritis in China and synthesis of one new immunosuppressive alkaloid was achieved. These compounds, including the crude extracts of this herb, exhibited strong activities in the inhibition of T and B cell proliferation.

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