2. Academic Validation
  3. Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids

Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids

  • Bioorg Med Chem Lett. 2006 Jul 1;16(13):3459-62. doi: 10.1016/j.bmcl.2006.04.011.
Brent R Stranix 1,  Jean-François Lavallée,  Guy Sévigny,  Jocelyn Yelle,  Valérie Perron,  Nicholas LeBerre,  Dominik Herbart,  Jinzi J Wu
Affiliations

Affiliation

  • 1 Ambrilia Biopharma Inc., 1000 chemin du Golf, Verdun, QC, Canada H3E 1H4. bstranix@ambrilia.com
PMID: 16644213 DOI: 10.1016/j.bmcl.2006.04.011
Abstract

A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic Amino acids were synthesized using an efficient synthetic route. Evaluation of these novel Protease Inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.

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