2. Academic Validation
  3. New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum

New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum

  • Bioorg Med Chem Lett. 2005 Jun 2;15(11):2776-80. doi: 10.1016/j.bmcl.2005.03.103.
Takahiro Hosoya 1,  Yukinori Yamamoto,  Yoshimasa Uehara,  Masahiko Hayashi,  Kanki Komiyama,  Masami Ishibashi
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Chiba University, Japan.
PMID: 15911254 DOI: 10.1016/j.bmcl.2005.03.103
Abstract

Two new bisindole Alkaloids, 6-hydroxystaurosporinone (1) and 5,6-dihydroxyarcyriaflavin A (2) were isolated from field-collected fruit bodies of a myxomycete Lycogala epidendrum, along with eight known bisindoles (3-10). The structures of these new compounds were determined on the basis of spectroscopic data. Compounds 1 and 2 showed cytotoxicity against HeLa, Jurkat, and vincristine resistant KB/VJ300 cells, and compound 1, particularly, inhibited protein tyrosine kinase activity.

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