2. Academic Validation
  3. Cytotoxic neolignans: an SAR study

Cytotoxic neolignans: an SAR study

  • Bioorg Med Chem Lett. 2005 Jan 3;15(1):163-6. doi: 10.1016/j.bmcl.2004.10.011.
Zwe-Ling Kong 1,  Shin-Cheng Tzeng,  Yeuk-Chuen Liu
Affiliations

Affiliation

  • 1 Food Science Department, National Taiwan Ocean University, Keelung, Taiwan, ROC.
PMID: 15582432 DOI: 10.1016/j.bmcl.2004.10.011
Abstract

The neolignans, magnolol 1 and honokiol 2 have been reported to inhibit the growth of several tumor cell lines in vitro and in vivo. The chemical structure of magnolol and honokiol consists of biphenyl skeleton with phenolic and allylic functionalities. Analogs of 1 and 2 containing different substitution have been studies for their effect on the growth of Hep-G2 and their structure-activity relationships were reported in this work.

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