2. Academic Validation
  3. Enzymatic synthesis of trehalose esters having lipophilicity

Enzymatic synthesis of trehalose esters having lipophilicity

  • J Biotechnol. 2003 Feb 13;100(3):203-8. doi: 10.1016/s0168-1656(02)00224-9.
T Raku 1,  M Kitagawa,  H Shimakawa,  Y Tokiwa
Affiliations

Affiliation

  • 1 New Energy and Industrial Technology Development Organization (NEDO), Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
PMID: 12443851 DOI: 10.1016/s0168-1656(02)00224-9
Abstract

To improve trehalose lipophilicity, trehalose was regioselectively esterified with vinyl fatty acid esters in dimethyl formamide by protease from Bacillus subtilis to give 6-O-lauroyltrehalose, 6-O-myristoyltrehalose, 6-O-palmitoyltrehalose, 6-O-stearoyltrehalose, 6-O-oleoyltrehalose and 6-O-linoleoyltrehalose. The influence of structural variation by changing fatty acid substitute was examined by measurement of the surface tension and biodegradability.

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