2. Academic Validation
  3. Synthesis and profile of SCH351591, a novel PDE4 inhibitor

Synthesis and profile of SCH351591, a novel PDE4 inhibitor

  • Bioorg Med Chem Lett. 2002 Jun 17;12(12):1621-3. doi: 10.1016/s0960-894x(02)00225-1.
Motasim Billah 1,  Nicola Cooper,  Francis Cuss,  Richard J Davenport,  Hazel J Dyke,  Robert Egan,  Ashit Ganguly,  Lewis Gowers,  Duncan R Hannah,  Alan F Haughan,  Hannah J Kendall,  Christopher Lowe,  Michael Minnicozzi,  John G Montana,  Robert Naylor,  Janet Oxford,  Joanna C Peake,  John J Piwinski,  Karen A Runcie,  Verity Sabin,  Andrew Sharpe,  Neng-Yang Shih,  Julie B H Warneck
Affiliations

Affiliation

  • 1 Schering-Plough Corporation, Galloping Hill Road, Kenilworth, NJ 07033-0530, USA.
PMID: 12039576 DOI: 10.1016/s0960-894x(02)00225-1
Abstract

The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).

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