2. Academic Validation
  3. Four new bioactive pyrrole-derived alkaloids from the marine sponge Axinella brevistyla

Four new bioactive pyrrole-derived alkaloids from the marine sponge Axinella brevistyla

  • J Nat Prod. 2001 Dec;64(12):1576-8. doi: 10.1021/np010280b.
S Tsukamoto 1,  K Tane,  T Ohta,  S Matsunaga,  N Fusetani,  R W van Soest
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan. sachiko@dbs.p.kanazawa-u.ac.jp
PMID: 11754618 DOI: 10.1021/np010280b
Abstract

Four new Alkaloids (1-4) were isolated from the marine Sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The Alkaloids 1-4 were Antifungal against the yeast Saccharomyces cerevisiae at <1.0, <1.0, 30, and 100 microg/disk, respectively. Compounds 1-3 also exhibited cytotoxicity against L1210 cells with IC(50) values of 1.1, 0.66, and 2.5 microg/mL, respectively.

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