2. Academic Validation
  3. The absolute configuration of belactin A, a beta-lactone-containing serine carboxypeptidase inhibitor: importance of the beta-lactone structure for serine carboxypeptidase inhibition

The absolute configuration of belactin A, a beta-lactone-containing serine carboxypeptidase inhibitor: importance of the beta-lactone structure for serine carboxypeptidase inhibition

  • J Enzyme Inhib. 1999;14(6):437-46. doi: 10.3109/14756369909030334.
S Murakami 1,  Y Takahashi,  T Takeuchi,  Y Kodama,  T Aoyagi
Affiliations

Affiliation

  • 1 Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 10536877 DOI: 10.3109/14756369909030334
Abstract

The absolute configuration of belactin A, a beta-lactone-containing serine Carboxypeptidase Inhibitor was studied by a crystal X-ray diffraction analysis and its absolute structure was determined to be (2R,3S)-2-¿(3S)-3-[(2-amino-5-chlorophenyl)carboxamido]-1,1-dimethyl-2-o xobutyl¿-3-methyl-4-oxooxetane. The importance of the beta-lactone structure for inhibitory activity was found by preparing several derivatives of belactin A.

Figures
Products