2. Academic Validation
  3. BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties

BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties

  • J Antibiot (Tokyo). 1998 Dec;51(12):1081-6. doi: 10.7164/antibiotics.51.1081.
H Okada 1,  S Kamiya,  Y Shiina,  H Suwa,  M Nagashima,  S Nakajima,  H Shimokawa,  E Sugiyama,  H Kondo,  K Kojiri,  H Suda
Affiliations

Affiliation

  • 1 Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
PMID: 10048566 DOI: 10.7164/antibiotics.51.1081
Abstract

A new antifungal Antibiotic, BE-31405, was isolated from the culture broth of a Fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic Fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells.

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