2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. Tyrosinase Ephrin Receptor VEGFR PDGFR FLT3 Tie
  4. LY2457546

LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia.

For research use only. We do not sell to patients.

LY2457546

LY2457546 Chemical Structure

CAS No. : 908265-94-1

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LY2457546 Related Antibodies

Top Publications Citing Use of Products

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EphA

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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PDGFR PDGFRβ PDGFRα

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Tie2

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Description

LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia[1].

IC50 & Target[1]

VEGFR2

 

PDGFRβ

 

Tie2

 

Molecular Weight

504.48

Formula

C28H20F4N4O
CAS No.
SMILES

O=C(CC1=CC=C(C2=CN=C3C=C(C4=CC(C)=NC=C4)C=CN32)C=C1F)NC5=CC=CC(C(F)(F)F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY2457546 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY2457546908265-94-1LY 2457546LY-2457546TyrosinaseEphrin ReceptorVEGFRPDGFRFLT3TieVascular endothelial growth factor receptorPlatelet-derived growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Angiopoietin receptoranti-angiogenicVEGFR2PDGFRβFLT-3Tie-2EphleukemiacancerInhibitorinhibitorinhibit

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