LSD1-IN-47

Cat. No.: HY-179229: Data Sheet Handling Instructions
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LSD1-IN-47 is a highly efficient PROTAC degrader targeting LSD1 (IC₅₀ = 43 nM). LSD1-IN-47 does not alter LSD1 protein levels and does not increase the histone marker H3K4me2. LSD1-IN-47 can be used for the study of colon carcinoma.
(Pink: LSD1 ligand (HY-17447A); Blue: VHL ligand (HY-125845); Black: linker).

For research use only. We do not sell to patients.

LSD1-IN-47 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

LSD1-IN-47 is a highly efficient PROTAC degrader targeting LSD1 (IC₅₀ = 43 nM). LSD1-IN-47 does not alter LSD1 protein levels and does not increase the histone marker H3K4me2. LSD1-IN-47 can be used for the study of colon carcinoma^[1]. (Pink: LSD1 ligand (HY-17447A); Blue: VHL ligand (HY-125845); Black: linker).

In Vitro

LSD1-IN-47 (Compound 52) (0.2-20 μM, 24-72 h) does not significantly alter LSD1 protein levels in HCT116 (human colon carcinoma cells) cells, and does not increase the histone marker H3K4me2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HCT116 cells
Concentration:	0.2 μM, 2 μM, 20 μM
Incubation Time:	24 h, 48 h, 72 h
Result:	Did not induce LSD1 degradation or affect H3K4me2 levels.

Molecular Weight

787.07

Formula

C₄₄H₆₂N₆O₅S

SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCCCNC(C4=CC=C([C@H]5[C@H](N)C5)C=C4)=O)=O)=O)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Coulson ME, et al. Synthetic and structure-activity studies of SP2577 and TCP towards LSD1 targeting PROTACs. RSC Med Chem. 2025 Aug 5;16(10):4952-4959.

LSD1-IN-47 Related Classifications

Cancer

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-47PROTACsHistone DemethylaseLSD1TranylcypromineTCPHCT116 cellsInhibitorinhibitorinhibit

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