L-Proline-¹³C₅

Name: L-Proline- 13 C 5
Brand: MedChemExpress
SKU: HY-Y0252S
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y0252S Purity: 99.00%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

L-Proline-¹³C₅ is the ¹³C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

For research use only. We do not sell to patients.

L-Proline-¹³C₅ Chemical Structure

CAS No. : 201740-83-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Proline-¹³C₅:

L-Proline In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Proline-¹³C₅ is the ¹³C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

120.09

Formula

¹³C₅H₉NO₂

CAS No.

201740-83-2

Appearance

Solid

Color

White to off-white

SMILES

O[13C]([13C@@H]1[13CH2][13CH2][13CH2]N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (1040.85 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.3268 mL	41.6341 mL	83.2681 mL
5 mM	1.6654 mL	8.3268 mL	16.6536 mL
10 mM	0.8327 mL	4.1634 mL	8.3268 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (832.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.00%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	8.3268 mL	41.6341 mL	83.2681 mL	208.1703 mL
	5 mM	1.6654 mL	8.3268 mL	16.6536 mL	41.6341 mL
	10 mM	0.8327 mL	4.1634 mL	8.3268 mL	20.8170 mL
	15 mM	0.5551 mL	2.7756 mL	5.5512 mL	13.8780 mL
	20 mM	0.4163 mL	2.0817 mL	4.1634 mL	10.4085 mL
	25 mM	0.3331 mL	1.6654 mL	3.3307 mL	8.3268 mL
	30 mM	0.2776 mL	1.3878 mL	2.7756 mL	6.9390 mL
	40 mM	0.2082 mL	1.0409 mL	2.0817 mL	5.2043 mL
	50 mM	0.1665 mL	0.8327 mL	1.6654 mL	4.1634 mL
	60 mM	0.1388 mL	0.6939 mL	1.3878 mL	3.4695 mL
	80 mM	0.1041 mL	0.5204 mL	1.0409 mL	2.6021 mL
	100 mM	0.0833 mL	0.4163 mL	0.8327 mL	2.0817 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.