2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. MEK VEGFR FLT3 PDGFR
  4. L-783277

L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma.

For research use only. We do not sell to patients.

L-783277

L-783277 Chemical Structure

CAS No. : 791807-02-8

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L-783277 Related Antibodies

Top Publications Citing Use of Products

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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PDGFR PDGFRβ PDGFRα

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Description

L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma[1][2].

Molecular Weight

364.39

Formula

C19H24O7
CAS No.
SMILES

O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2CCC[C@H](O)[C@H](O)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-783277 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-783277791807-02-8L783277L 783277MEKVEGFRFLT3PDGFRMitogen-activated protein kinase kinaseMAPKKMAP2KVascular endothelial growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Platelet-derived growth factor receptorMEK inhibitorH295R cellsadrenocortical carcinomaInhibitorinhibitorinhibit

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