2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. 17β-HSD PPAR
  4. HSD17B13/PPAR modulator-1

HSD17B13/PPAR modulator-1 (Compound 17) is a HSD17B13/PPAR multitarget modulator. HSD17B13/PPAR modulator-1 is an inhibitor of HSD17B13, with its IC50 value being 0.91 μM. HSD17B13/PPAR modulator-1 is a PPAR agonist, with the EC50 values for PPARα, PPARδ, and PPARγ being 1.55, 0.12, and 0.01 μM respectively. HSD17B13/PPAR modulator-1 can significantly improve liver function, regulate lipid metabolism, alleviate fibrosis, and exert antioxidant and anti-inflammatory effects in the model of metabolic dysfunction-related steatohepatitis (MASH). HSD17B13/PPAR modulator-1 can be used for the study of MASH.

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HSD17B13/PPAR modulator-1

HSD17B13/PPAR modulator-1 Chemical Structure

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HSD17B13/PPAR modulator-1 Related Antibodies

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Description

HSD17B13/PPAR modulator-1 (Compound 17) is a HSD17B13/PPAR multitarget modulator. HSD17B13/PPAR modulator-1 is an inhibitor of HSD17B13, with its IC50 value being 0.91 μM. HSD17B13/PPAR modulator-1 is a PPAR agonist, with the EC50 values for PPARα, PPARδ, and PPARγ being 1.55, 0.12, and 0.01 μM respectively. HSD17B13/PPAR modulator-1 can significantly improve liver function, regulate lipid metabolism, alleviate fibrosis, and exert antioxidant and anti-inflammatory effects in the model of metabolic dysfunction-related steatohepatitis (MASH). HSD17B13/PPAR modulator-1 can be used for the study of MASH[1].

IC50 & Target[1]

PPARα

1.55 μM (EC50)

PPARδ

0.12 μM (EC50)

PPARγ

0.01 μM (EC50)

Molecular Weight

598.63

Formula

C31H29F3N2O5S
SMILES

O=C(C1=C(C)N=C(S1)C2=CC(F)=C(F)C(O)=C2F)N(CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C)CC4=CC=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSD17B13/PPAR modulator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSD17B13/PPAR modulator-117β-HSDPPAR17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenasePeroxisome proliferator-activated receptorsSD17B13multitarget modulatormetabolic dysfunction-associated steatohepatitis (MASH)compound 17Inhibitorinhibitorinhibit

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