2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6 ligand-7

HDAC6 ligand-7 (Compound 16a) is a positron emission tomography (PET) tracer for the deacetylase 6 (HDAC6) enzyme with a Kd value of 1.66 nM. HDAC6 ligand-7 exhibits excellent HDAC6 inhibitory activity, with IC50 values of 2.7 and 3.7 nM for hHDAC6 and mHDAC6, respectively, and has high selectivity for HDAC1/4/7/8. HDAC6 ligand-7 after being radioactively labeled with fluorine-18, [¹⁸F]HDAC6 ligand-7 shows varying degrees of radioactive uptake in PET, which can reflect the specific binding to HDAC6. HDAC6 ligand-7 can be used for the study of HDAC6 imaging.

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HDAC6 ligand-7

HDAC6 ligand-7 Chemical Structure

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HDAC6 ligand-7 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC6 ligand-7 (Compound 16a) is a positron emission tomography (PET) tracer for the deacetylase 6 (HDAC6) enzyme with a Kd value of 1.66 nM. HDAC6 ligand-7 exhibits excellent HDAC6 inhibitory activity, with IC50 values of 2.7 and 3.7 nM for hHDAC6 and mHDAC6, respectively, and has high selectivity for HDAC1/4/7/8. HDAC6 ligand-7 after being radioactively labeled with fluorine-18, [¹⁸F]HDAC6 ligand-7 shows varying degrees of radioactive uptake in PET, which can reflect the specific binding to HDAC6. HDAC6 ligand-7 can be used for the study of HDAC6 imaging[1].

IC50 & Target[1]

hHDAC6

2.7 nM (IC50)

hHDAC1

1300 nM (IC50)

hHDAC4

>10000 nM (IC50)

hHDAC7

4400 nM (IC50)

hHDAC8

640 nM (IC50)

Molecular Weight

326.33

Formula

C17H15FN4O2
SMILES

O=C(NO)C1=CC=C(CN2N=C(C)C=C2C3=NC(F)=CC=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6 ligand-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6 ligand-7HDACHistone deacetylasesHDAC6 PET tracerpyrazole derivativesfluorine-18 labelinghistone deacetylase inhibitorblood-brain barrier penetrationneurodegenerative diseasesnonhuman primate imagingspecificity validationkinetic analysisquantitative PET imagingInhibitorinhibitorinhibit

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HDAC6 ligand-7
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