HCA-6 

HCA-6 is a calcium-channel and P-glycoprotein blocker. HCA-6 can induce cancer cells apoptosis and increase anticancer activity of Cisplatin (HY-17394). HCA-6 also exhibits antibacterial activity against Bacillus subtilis. HCA-6 can be used for the research of cancer and infection, such as breast cancer^[1].

HCA-6 (2 μM, 24 h) significantly enhances the anticancer activity of Cisplatin (HY-17394) in 4T1, MDA-MB-231, HeLa, HepG2, and SW480 cells, reduces the IC₅₀ of Cisplatin in HeLa cells to 3.65 μM and increases the inhibition rate by 61.21%^[1].
HCA-6 (10 μM) inhibits P-glycoprotein (P-gp)-mediated efflux of rhodamine 123^[1].
HCA-6 (10 μg/mL) induces apoptosis in Hela cells^[1].
HCA-6 (0.25-1 mg/mL) exhibits antibacterial activity against Bacillus subtilis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

692.60

C₃₀H₃₃FN₄O₁₄

O[C@@H]1[C@H](O)[C@@H](COC(COC2=CC=C(C3C(C(OCC)=O)=C(C)NC(C)=C3C(OCC)=O)C=C2[N+]([O-])=O)=O)O[C@H]1N(C(N4)=O)C=C(F)C4=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen G, et al. Novel dihydropyridines as potential calcium-channel and P-glycoprotein blockers applicable for chemotherapy sensitization. Bioorg Chem. 2025 Oct;165:109072.  [Content Brief]