2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Guanylate Cyclase Endogenous Metabolite
  4. Guanylin(human)

Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

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Guanylin(human)

Guanylin(human) Chemical Structure

CAS No. : 183200-12-6

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Based on 1 publication(s) in Google Scholar

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Description

Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism[1][2].

Molecular Weight

1458.66

Formula

C58H87N15O21S4
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

PGTCEICAYAACTGC (Disulfide bridge:Cys4-Cys12;Cys7-Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (68.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6856 mL 3.4278 mL 6.8556 mL
5 mM 0.1371 mL 0.6856 mL 1.3711 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6856 mL 3.4278 mL 6.8556 mL 17.1390 mL
5 mM 0.1371 mL 0.6856 mL 1.3711 mL 3.4278 mL
10 mM 0.0686 mL 0.3428 mL 0.6856 mL 1.7139 mL
15 mM 0.0457 mL 0.2285 mL 0.4570 mL 1.1426 mL
20 mM 0.0343 mL 0.1714 mL 0.3428 mL 0.8570 mL
25 mM 0.0274 mL 0.1371 mL 0.2742 mL 0.6856 mL
30 mM 0.0229 mL 0.1143 mL 0.2285 mL 0.5713 mL
40 mM 0.0171 mL 0.0857 mL 0.1714 mL 0.4285 mL
50 mM 0.0137 mL 0.0686 mL 0.1371 mL 0.3428 mL
60 mM 0.0114 mL 0.0571 mL 0.1143 mL 0.2857 mL
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Guanylin(human) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanylin(human)183200-12-6Guanylate CyclaseEndogenous MetabolitecGMPendogenouspeptideintestinalgastrointestinalelectrolyteadInhibitorinhibitorinhibit

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