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  3. Molecular Glues
  4. GSPT1 degrader-13

GSPT1 degrader-13 is a selective molecular glue GSPT1 degrader. GSPT1 degrader-13 exhibits antiproliferative activity against cancer cells in a CRBN- and GSPT1-dependent manner. GSPT1 degrader-13 can be used for leukemia research.

For research use only. We do not sell to patients.

GSPT1 degrader-13

GSPT1 degrader-13 Chemical Structure

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GSPT1 degrader-13 Related Antibodies

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Description

GSPT1 degrader-13 is a selective molecular glue GSPT1 degrader. GSPT1 degrader-13 exhibits antiproliferative activity against cancer cells in a CRBN- and GSPT1-dependent manner. GSPT1 degrader-13 can be used for leukemia research[1].

In Vitro

GSPT1 degrader-13 (compound 1) (3 days) exhibits anti-proliferative activity against cancer cells, with EC50s of 0.18 (MOLT4), 0.19 (MV4;11), and 12 μM (BE(2)-C)[1].
GSPT1 degrader-13 (3 h) shows GSPT1 degradation activity in MOLT4, MV4;11, and BE(2)-C cells, with EC50s of 0.28, 0.28, and 8 μM, respectively[1].
GSPT1 degrader-13 (3 μM, 3 h) degrades GSPT1 in wild-type MOLT4, MV4;11, and BE(2)-C cells, but its degradation activity is blocked by CRBN KO cells and G575N mutant cells, indicating that it degrades GSPT1 in a CRBN- and GSPT1-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSPT1 degrader-13 Related Antibodies
Molecular Weight

506.96

Formula

C22H23ClN4O6S
SMILES

O=C(N1)C(N2CC3=CC(NS(=O)(NCCOC4=C(C=CC=C4C)Cl)=O)=CC=C3C2=O)CCC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSPT1 degrader-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSPT1 degrader-13Molecular GluesGSPT1CRBNleukemiaMOLT4MV4;11Inhibitorinhibitorinhibit

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