2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. GSK 1997132B

GSK 1997132B is a benzimidazole-based PPARγ partial agonist that can cross the blood-brain barrier with a pEC50 value of 8.0. GSK 1997132B has no significant effect on PPARα/δ. GSK 1997132B improves the problem of high blood clearance rate of earlier compounds, avoiding side effects such as weight gain and edema. GSK 1997132B can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

GSK 1997132B

GSK 1997132B Chemical Structure

CAS No. : 1168138-37-1

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GSK 1997132B Related Antibodies

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Description

GSK 1997132B is a benzimidazole-based PPARγ partial agonist that can cross the blood-brain barrier with a pEC50 value of 8.0. GSK 1997132B has no significant effect on PPARα/δ. GSK 1997132B improves the problem of high blood clearance rate of earlier compounds, avoiding side effects such as weight gain and edema. GSK 1997132B can be used for research on Alzheimer's disease[1].
IC50 & Target[1]

PPAR-γ

8 (pEC50)

Molecular Weight

420.45

Formula

C24H22F2N4O
CAS No.
SMILES

O=C(N[C@H](CC)C1=CC=CC=C1)C2=CC=C3N(C(C)=NC3=C2)CC4=NC=C(C=C4F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK 1997132B Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK 1997132B1168138-37-1PPARPeroxisome proliferator-activated receptorsPartial AgonistAlzheimer's diseaseblood-brain barrierselectivtyInhibitorinhibitorinhibit

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