2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. GR125487

GR125487 is a highly selective and potent 5-HT4 receptor (5-HT4 receptor) antagonist with a Kd value of 0.1 nM. GR125487 has an extremely low affinity for 5-HT3 receptors (Kd > 1 μM). GR125487 completely antagonizes the memory-promoting effect of BIMU1, and its administration alone has no significant effect on basic social memory. GR125487 can be used for the study of social olfactory memory.

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GR125487

GR125487 Chemical Structure

CAS No. : 144625-67-2

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GR125487 Related Antibodies

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Description

GR125487 is a highly selective and potent 5-HT4 receptor (5-HT4 receptor) antagonist with a Kd value of 0.1 nM. GR125487 has an extremely low affinity for 5-HT3 receptors (Kd > 1 μM). GR125487 completely antagonizes the memory-promoting effect of BIMU1, and its administration alone has no significant effect on basic social memory. GR125487 can be used for the study of social olfactory memory[1].
IC50 & Target[1]

5-HT4 Receptor

0.1 nM (Kd)

Molecular Weight

427.49

Formula

C19H26FN3O5S
CAS No.
SMILES

O=C(OCC1CCN(CCNS(=O)(=O)C)CC1)C2=C(OC)NC=3C=CC(F)=CC32
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GR125487 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR125487144625-67-2GR 125487GR-1254875-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT4 receptor antagonistsocial olfactory memoryBIMU1receptor selectivitybrain concentrationmemory enhancementserotonin receptorscognitive functionpharmacological toolInhibitorinhibitorinhibit

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