Dock2 - dedicator of cyto-kinesis 2 Gene

Mus musculus

Also known as Hch; MBC; CED-5

Gene ID: 94176 | Gene type: protein coding

About Dock2

Summary

Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Apr 2022]

Dock2 Products(1)

mRNA	Protein	Name
NM_033374.3	NP_203538.2	dedicator of cytokinesis protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	12871644	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	12871644	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	12871644	MGI
acts upstream of or within alpha-beta T cell activation	IMP IMP: Inferred from mutant phenotype	12871644	MGI
acts upstream of or within alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	12871644	MGI
acts upstream of or within chemotaxis	IMP IMP: Inferred from mutant phenotype	11518968	MGI
acts upstream of or within cytoskeleton organization	IDA IDA: Inferred from direct assay	11518968	MGI
acts upstream of or within establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	12871644	MGI
acts upstream of or within immunological synapse formation	IMP IMP: Inferred from mutant phenotype	12871644	MGI
involved in macropinocytosis	IMP IMP: Inferred from mutant phenotype	21892172	MGI
acts upstream of or within membrane raft polarization	IMP IMP: Inferred from mutant phenotype	12871644	MGI
involved in myeloid dendritic cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	21892172	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	12871644	MGI
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	21892172	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	12871644	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dedicator of cytokinesis protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153128	DOCK2-IN-1	Inhibitor	96.20%	Unkown
HY-111355	Cholesterol sulfate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dock2	NCBI	NCBI:1794

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