Trpc6 - transient receptor potential cation channel, subfamily C, member 6 Gene

Rattus norvegicus

Also known as Trrp6

Gene ID: 89823 | Gene type: protein coding

About Trpc6

Summary

Enables several functions, including ATPase binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; generation of neurons; and positive regulation of peptidyl-threonine phosphorylation. Located in plasma membrane. Used to study focal segmental glomerulosclerosis; kidney disease; and transient cerebral ischemia. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]

Trpc6 Products(1)

mRNA	Protein	Name
NM_053559.1	NP_446011.1	short transient receptor potential channel 6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	16025302	RGD
enables actin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables actinin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables calcium channel activity	IDA IDA: Inferred from direct assay	20501650	RGD
enables clathrin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	11278449	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16025302	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	20501650	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	19889962	RGD
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	22764246	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	20479868	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	11788346	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	22764246	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	20479868	RGD
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	22699894	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

short transient receptor potential channel 6

transient receptor protein 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111925	BI-749327	Antagonist	99.91%	Unkown
HY-111098	GSK1702934A	Agonist	99.11%	Unkown
HY-116330A	Hyperforin dicyclohexylammonium salt		99.52%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-12949	ML204	Inhibitor	98.45%	Unkown
HY-15699	SAR7334	Inhibitor	99.82%	Unkown
HY-108457	9-Phenanthrol	Inhibitor	99.61%	Unkown
HY-122051	AC1903	Inhibitor	99.80%	Unkown
HY-15699A	SAR7334 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-101795	Larixyl acetate	Inhibitor	99.46%	Unkown
HY-12949A	ML204 hydrochloride	Inhibitor	99.74%	Unkown
HY-136190	TRPC6-PAM-C20	Agonist	99.78%	Unkown
HY-W744699	Larixol	Inhibitor	95.52%	Unkown
HY-148129	TRPC6-IN-3	Inhibitor	99.62%	Unkown
HY-101547	TRPC6-IN-1	Inhibitor	99.71%	Unkown
HY-111527	PPZ2		99.92%	Unkown
HY-N10756	Hyp9	Agonist	99.90%	Unkown
HY-133012	GFB-8438	Inhibitor	99.74%	Unkown
HY-112298	DS88790512	Inhibitor	/	Unkown
HY-116330	Hyperforin		/	Unkown
HY-120818	TRPC3/6-IN-3		/	Unkown
HY-121519	GSK2332255B	Antagonist	/	Unkown
HY-145151	TRPC6-IN-2		/	Unkown
HY-153455	TRPC3/6-IN-2	Inhibitor	/	Unkown
HY-172600	TRPC6 antagonist-1	Antagonist	/	Unkown
HY-RS15109	TRPC6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W745090	Isomaltulose monohydrate		/	Unkown
HY-147357	TRPC3/6-IN-1	Inhibitor	/	Unkown
HY-RS16595	Trpc6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23029	Trpc6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpc6	NCBI	NCBI:7225

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