2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Hyp9

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI).

For research use only. We do not sell to patients.

Hyp9 Chemical Structure

Hyp9 Chemical Structure

CAS No. : 3118-34-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 2 publication(s) in Google Scholar

Hyp9 Related Antibodies

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Description

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI)[1].

In Vitro

HYP9 (0, 1, 5, 10, 15, 20, 25, 30 µM; 72 h) inhibits astrocyte proliferation in a dose-dependent manner[1].
HYP9 dramatically suppresses AP4 overexpression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hyp9 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: CTX-TNA2 rat astrocytes
Concentration: 0, 1, 5, 10, 15, 20, 25, 30 µM
Incubation Time: 72 h
Result: Significantly inhibit astrocyte proliferation at 5-30 µM.
In Vivo

HP9 (intrathecally; 5 μg; 1, 3, 5, and 7 days) inhibits astrocyte activation and proliferation by inhibiting AQP4 in SCl rats in vivo models and that it preserves neuronal survival and functional recovery after SCI[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley Rats (180-220 g; adult female)[1]
Dosage: 5 μg
Administration: Intrathecally; 1, 3, 5, and 7 days
Result: Inhibited activation and proliferation of astrocytes in a rat SCI model.
Reduced apoptosis and promotes neuronal survival in SCI rats by TRPC6/AQP4 signaling pathway.
Facilitated functional motor recovery via TRPC6/AQP4 signaling pathway in SCI rats.
Molecular Weight

322.40

Formula

C18H26O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCC)C1=C(C=C(C(C(CCCCC)=O)=C1O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (310.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1017 mL 15.5087 mL 31.0174 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

SDS (251 KB)

COA (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1017 mL 15.5087 mL 31.0174 mL 77.5434 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL 15.5087 mL
10 mM 0.3102 mL 1.5509 mL 3.1017 mL 7.7543 mL
15 mM 0.2068 mL 1.0339 mL 2.0678 mL 5.1696 mL
20 mM 0.1551 mL 0.7754 mL 1.5509 mL 3.8772 mL
25 mM 0.1241 mL 0.6203 mL 1.2407 mL 3.1017 mL
30 mM 0.1034 mL 0.5170 mL 1.0339 mL 2.5848 mL
40 mM 0.0775 mL 0.3877 mL 0.7754 mL 1.9386 mL
50 mM 0.0620 mL 0.3102 mL 0.6203 mL 1.5509 mL
60 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2924 mL
80 mM 0.0388 mL 0.1939 mL 0.3877 mL 0.9693 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7754 mL
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Hyp9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hyp93118-34-1Hyp 9Hyp-9TRP ChannelTransient receptor potential channelstransient receptor potential canonical 6 (TRPC6)spinal cord injury (SCI)AQP4Inhibitorinhibitorinhibit

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