2. Gene
  3. Enpp1 - ectonucleotide pyrophosphatase/phosphodiesterase 1 Gene

Enpp1 - ectonucleotide pyrophosphatase/phosphodiesterase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pc1; Npps

Gene ID: 85496 | Gene type: protein coding

About Enpp1

Summary

Enables phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Located in several cellular components, including dendrite; neuronal cell body; and synapse. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Enpp1 Products(1)

mRNA Protein Name
NM_053535.2 NP_445987.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphodiesterase I activity IDA
IDA: Inferred from direct assay
17187902 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to acidic pH IEP
IEP: Inferred from expression pattern
26033523 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
21168404 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
24157151 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
24157151 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
10231554 RGD
involved in olfactory bulb development IEP
IEP: Inferred from expression pattern
18565716 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
26746151 RGD
involved in striatum development IEP
IEP: Inferred from expression pattern
18565716 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical dendrite IDA
IDA: Inferred from direct assay
17046728 RGD
located in basal dendrite IDA
IDA: Inferred from direct assay
17046728 RGD
located in cell body IDA
IDA: Inferred from direct assay
22086174 RGD
located in cell projection IDA
IDA: Inferred from direct assay
22086174 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17046728 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
19474315 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 1

E-NPP 1

phosphodiesterase I/nucleotide pyrophosphatase 1

plasma-cell membrane glycoprotein PC-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (30)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129490 Enpp-1-IN-1 Inhibitor 99.19% Unkown
HY-147389 Enpp-1-IN-14 Inhibitor 99.67% Unkown
HY-143256 Enpp-1-IN-12 Inhibitor 99.06% Unkown
HY-139362 Enpp-1-IN-2 Inhibitor 99.16% Unkown
HY-153335 Enpp-1-IN-16 Inhibitor 99.11% Unkown
HY-155457 Enpp-1-IN-19 99.28% Unkown
HY-158791 Enpp-1-IN-21 Inhibitor 96.10% Unkown
HY-163343 Enpp-1-IN-20 98.06% Unkown
HY-143254 Enpp-1-IN-10 Inhibitor 98.64% Unkown
HY-145063 Enpp-1-IN-5 Inhibitor 98.16% Unkown
HY-143255 Enpp-1-IN-11 Inhibitor / Unkown
HY-145062 Enpp-1-IN-4 Inhibitor / Unkown
HY-145064 Enpp-1-IN-6 Inhibitor / Unkown
HY-145065 Enpp-1-IN-7 Inhibitor / Unkown
HY-145069 Enpp-1-IN-8 Inhibitor / Unkown
HY-145070 Enpp-1-IN-9 Inhibitor / Unkown
HY-147998 Enpp-1-IN-13 Inhibitor / Unkown
HY-153334 Enpp-1-IN-15 Inhibitor / Unkown
HY-153398 Enpp-1-IN-17 Inhibitor / Unkown
HY-157522 NCI-14465 Inhibitor / Unkown
HY-162911 Enpp-1-IN-22 Inhibitor / Unkown
HY-162912 Enpp-1-IN-23 Inhibitor / Unkown
HY-168147 Enpp-1-IN-24 Inhibitor / Unkown
HY-168491 Enpp-1-IN-25 / Unkown
HY-176708 ISM5939 Inhibitor / Unkown
HY-RS04387 ENPP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-156205 CdnP-IN-1 Inhibitor / Unkown
HY-169804 ENPP3 Inhibitor 1 Inhibitor / Unkown
HY-RS16545 Enpp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22977 Enpp1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Enpp1 NCBI NCBI:5167
Mus musculus Enpp1 NCBI NCBI:18605