Tmed10 - transmembrane p24 trafficking protein 10 Gene

Rattus norvegicus

Also known as Tmp21

Gene ID: 84599 | Gene type: protein coding

About Tmed10

Summary

Predicted to enable protein transmembrane transporter activity and syntaxin binding activity. Involved in several processes, including Golgi organization; response to alkaloid; and vesicle targeting, to, from or within Golgi. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum-Golgi intermediate compartment. Is integral component of membrane. Part of gamma-secretase complex. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10). [provided by Alliance of Genome Resources, Apr 2022]

Tmed10 Products(1)

mRNA	Protein	Name
NM_053467.1	NP_445919.1	transmembrane emp24 domain-containing protein 10 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11739402	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10214941	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	9914165	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	10893644	RGD
involved in regulated exocytosis	IEP IEP: Inferred from expression pattern	17101722	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	9288726	RGD
involved in vesicle targeting, to, from or within Golgi	IEP IEP: Inferred from expression pattern	17101722	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in COPI-coated vesicle	IDA IDA: Inferred from direct assay	10214941	RGD
located in Golgi membrane	IDA IDA: Inferred from direct assay	31455601	RGD
located in cis-Golgi network	IDA IDA: Inferred from direct assay	17101722	RGD
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	9914165	RGD
part of gamma-secretase complex	IDA IDA: Inferred from direct assay	19754663	RGD
located in membrane	IDA IDA: Inferred from direct assay	8663407	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18627576	RGD
located in zymogen granule membrane	IDA IDA: Inferred from direct assay	8663407	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane emp24 domain-containing protein 10

21 kDa transmembrane-trafficking protein	integral membrane protein Tmp21-I (p23)
p24 family protein delta-1	p24delta1
transmembrane emp24-like trafficking protein 10	transmembrane protein Tmp21
transmembrane trafficking protein 21

Tmed10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tmed10	Q63584	Gorasp2	Rattus norvegicus	Q9R064	Pull Down	11739402

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14635	TMED10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19272	Tmed10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25761	Tmed10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmed10	NCBI	NCBI:10972

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