2. Gene
  3. Nucb1 - nucleobindin 1 Gene

Nucb1 - nucleobindin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Nucb

Gene ID: 84595 | Gene type: protein coding

About Nucb1

Summary

Enables G-protein alpha-subunit binding activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Involved in regulation of protein targeting; response to cisplatin; and small GTPase mediated signal transduction. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and rough endoplasmic reticulum. Is extrinsic component of Golgi membrane. Orthologous to human NUCB1 (nucleobindin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nucb1 Products(2)

mRNA Protein Name
NM_053463.3 NP_445915.1 nucleobindin-1 precursor
NM_053463.2 NP_445915.1 nucleobindin-1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G-protein alpha-subunit binding IDA
IDA: Inferred from direct assay
9647645 RGD
enables calcium ion binding IDA
IDA: Inferred from direct assay
9647645 RGD
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
21653697 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19497050 RGD
Biological Process GO Annotation Evidence Reference Source
involved in regulation of protein targeting IDA
IDA: Inferred from direct assay
19497050 RGD
involved in small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
21653697 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Golgi cisterna membrane IDA
IDA: Inferred from direct assay
9647645 RGD
located in Golgi-associated vesicle IDA
IDA: Inferred from direct assay
9647645 RGD
located in early endosome IDA
IDA: Inferred from direct assay
19497050 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
15193541 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12403836 RGD
located in extrinsic component of Golgi membrane IDA
IDA: Inferred from direct assay
9647645 RGD
located in lumenal side of Golgi membrane IDA
IDA: Inferred from direct assay
9647645 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
19497050 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleobindin-1

CALNUC

bone 63 kDa calcium-binding protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-118319 MJN228 99.30% Unkown
HY-RS09654 NUCB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21674 Nucb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS28192 Nucb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nucb1 NCBI NCBI:4924