2. Gene
  3. Dcx - doublecortin Gene

Dcx - doublecortin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 84394 | Gene type: protein coding

About Dcx

Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. Studies in knockout mice lacking this gene suggest that this gene has a cortical role in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. This gene is essential for neuronal migration, differentiation, and plasticity, is required for hippocampal development and also plays a role in dendrites development.[provided by RefSeq, Sep 2010]

Dcx Products(1)

mRNA Protein Name
NM_053379.3 NP_445831.3 neuronal migration protein doublecortin
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
14625554 RGD
involved in positive regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
19726658 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
22649224 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
19499587 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
25487013 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
33978223 RGD
located in axon IDA
IDA: Inferred from direct assay
22649224 RGD
located in dendrite IDA
IDA: Inferred from direct assay
19499587 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
33978223 RGD
located in growth cone IDA
IDA: Inferred from direct assay
19726658 RGD
located in microtubule IDA
IDA: Inferred from direct assay
19726658 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19726658 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
33978223 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal migration protein doublecortin

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117787 TUG-905 Agonist / Unkown
HY-RS03601 DCX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17791 Dcx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24259 Dcx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dcx NCBI NCBI:1641