2. Gene
  3. Nr1i2 - nuclear receptor subfamily 1, group I, member 2 Gene

Nr1i2 - nuclear receptor subfamily 1, group I, member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PXR

Gene ID: 84385 | Gene type: protein coding

About Nr1i2

Summary

Enables nuclear receptor activity. Predicted to be involved in several processes, including regulation of transcription by RNA polymerase II; xenobiotic catabolic process; and xenobiotic transport. Predicted to act upstream of or within negative regulation of transcription, DNA-templated and positive regulation of gene expression. Located in nucleus. Biomarker of cholestasis and epilepsy. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr1i2 Products(1)

mRNA Protein Name
NM_052980.2 NP_443212.1 nuclear receptor subfamily 1 group I member 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
10967130 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 1 group I member 2

nuclear receptor subfamily 1, group 1, member 2

orphan nuclear receptor PXR

pregnane X receptor (nuclear receptor sub family 1, group I, member 2)

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09534 NR1I2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22685 Nr1i2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29199 Nr1i2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1i2 NCBI NCBI:8856