ZMYND15 - zinc finger MYND-type containing 15 Gene

Homo sapiens

Also known as SPGF14

Gene ID: 84225 | Gene type: protein coding

About ZMYND15

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,739,833-4,746,119 (from NCBI)

This gene has 6 transcripts (splice variants), 138 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 15.6), lung (RPKM 3.5) and 10 other tissues.

Summary

This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase Enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

ZMYND15 Products(3)

mRNA	Protein	Name
NM_001136046.3	NP_001129518.1	zinc finger MYND domain-containing protein 15 isoform 1
NM_001267822.1	NP_001254751.1	zinc finger MYND domain-containing protein 15 isoform 3
NM_032265.2	NP_115641.1	zinc finger MYND domain-containing protein 15 isoform 2

ZMYND15 Protein Structure

zf-MYND

0
200
400
600
742 a.a.

Protein Preferred Names

Protein Names

zinc finger MYND domain-containing protein 15

Related Diseases

Diseases

Alias

Spermatogenic Failure 14

SPGF14

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Infertility

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16095	ZMYND15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZMYND15	VGNC	VGNC:67265
Bos taurus	ZMYND15	VGNC	VGNC:37204
Mus musculus	ZMYND15	MGD	MGI:3603821
Canis familiaris	ZMYND15	VGNC	VGNC:48653
Macaca mulatta	ZMYND15	VGNC	VGNC:79299
Rattus norvegicus	ZMYND15	RGD	RGD:1309845

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