2. Gene
  3. Nedd4l - neural precursor cell expressed, developmentally down-regulated gene 4-like Gene

Nedd4l - neural precursor cell expressed, developmentally down-regulated gene 4-like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nedd4b; NEDD4.2; Nedd4-2; 1300012C07Rik

Gene ID: 83814 | Gene type: protein coding

About Nedd4l

Summary

Enables Sodium Channel Inhibitor activity and ubiquitin protein Ligase activity. Acts upstream of or within several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of ion transport. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nedd4l Products(6)

mRNA Protein Name
NM_001114386.2 NP_001107858.1 E3 ubiquitin-protein ligase NEDD4-like isoform 1
NM_001404007.1 NP_001390936.1 E3 ubiquitin-protein ligase NEDD4-like isoform 3
NM_001404008.1 NP_001390937.1 E3 ubiquitin-protein ligase NEDD4-like isoform 4
NM_001404009.1 NP_001390938.1 E3 ubiquitin-protein ligase NEDD4-like isoform 4
NM_001404013.1 NP_001390942.1 E3 ubiquitin-protein ligase NEDD4-like isoform 5
NM_031881.3 NP_114087.2 E3 ubiquitin-protein ligase NEDD4-like isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17544362 MGI
enables sodium channel inhibitor activity IDA
IDA: Inferred from direct assay
11149908 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
20504882 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
21300902 MGI
acts upstream of or within negative regulation of sodium ion transport IDA
IDA: Inferred from direct assay
11149908 MGI
acts upstream of or within negative regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
18524855 MGI
acts upstream of or within negative regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
18524855 MGI
acts upstream of or within positive regulation of cation channel activity IGI
IGI: Inferred from genetic interaction
18981174 MGI
acts upstream of or within positive regulation of sodium ion transport IGI
IGI: Inferred from genetic interaction
18981174 MGI
acts upstream of or within regulation of bicellular tight junction assembly IDA
IDA: Inferred from direct assay
20504882 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
28212375 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
28212375 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
28212375 MGI
acts upstream of or within regulation of sodium ion transport IDA
IDA: Inferred from direct assay
32175648 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
28212375 MGI
involved in regulation protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
28212375 MGI
involved in regulation protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
28212375 MGI
acts upstream of or within response to salt stress IMP
IMP: Inferred from mutant phenotype
18524855 MGI
acts upstream of sodium ion transport IMP
IMP: Inferred from mutant phenotype
18524855 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
32175648 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28212375 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
28212375 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28212375 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase NEDD4-like

HECT-type E3 ubiquitin transferase NED4L

neural precursor cell expressed, developmentally down-regulated gene 4b

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09180 NEDD4L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17116 Nedd4l Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23561 Nedd4l Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nedd4l NCBI NCBI:23327