Wasf1 - WASP family, member 1 Gene

Mus musculus

Also known as Scar; WAVE; WAVE-1

Gene ID: 83767 | Gene type: protein coding

About Wasf1

Summary

Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and modification of postsynaptic actin Cytoskeleton. Acts upstream of or within lamellipodium morphogenesis. Located in lamellipodium; mitochondrial outer membrane; and postsynapse. Is expressed in several structures, including central nervous system; liver; spleen; testis; and tooth. Orthologous to human WASF1 (WASP family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Wasf1 Products(3)

mRNA	Protein	Name
NM_001379453.1	NP_001366382.1	actin-binding protein WASF1 isoform 1
NM_001379454.1	NP_001366383.1	actin-binding protein WASF1 isoform 2
NM_031877.3	NP_114083.1	actin-binding protein WASF1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12931191	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IMP IMP: Inferred from mutant phenotype	27605705	MGI
involved in dendrite extension	IMP IMP: Inferred from mutant phenotype	27605705	MGI
acts upstream of or within lamellipodium morphogenesis	IMP IMP: Inferred from mutant phenotype	17664349	MGI
involved in modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	16862120	MGI
involved in modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	16862120	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	27605705	MGI
involved in positive regulation of neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27605705	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	27605705	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17664349	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	15148305	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	12931191	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	12931191	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	16190876	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	16190876	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

actin-binding protein WASF1

wiskott-Aldrich syndrome protein family member 1

WAS protein family, member 1	WASP family 1
WASP family protein member 1	protein WAVE-1

Wasf1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Wasf1	Q8R5H6	Pik3r1	Mus musculus	P26450	Anti Bait CoIP	21946561

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15742	WASF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22917	Wasf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29431	Wasf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wasf1	NCBI	NCBI:8936

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