2. Gene
  3. Rtn4 - reticulon 4 Gene

Rtn4 - reticulon 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Nogo; Vp20; rat N; NI-250; Nogo-A; rat NogoA

Gene ID: 83765 | Gene type: protein coding

About Rtn4

Summary

Predicted to enable Cadherin binding activity; protein homodimerization activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of neuron projection regeneration; nervous system development; and positive regulation of dopamine secretion. Located in several cellular components, including endoplasmic reticulum; myelin sheath; and neuronal cell body. Is integral component of endoplasmic reticulum membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of visual epilepsy. Orthologous to human RTN4 (reticulon 4). [provided by Alliance of Genome Resources, Apr 2022]

Rtn4 Products(1)

mRNA Protein Name
NM_031831.2 NP_114019.2 reticulon-4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15673660 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15640160 RGD
Biological Process GO Annotation Evidence Reference Source
involved in axonal fasciculation IDA
IDA: Inferred from direct assay
20573699 RGD
involved in negative regulation of axon extension IDA
IDA: Inferred from direct assay
20573699 RGD
involved in negative regulation of axonogenesis IDA
IDA: Inferred from direct assay
10667796 RGD
involved in negative regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
18973596 RGD
involved in negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
19379790 RGD
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
19386232 RGD
involved in negative regulation of neuron projection regeneration IMP
IMP: Inferred from mutant phenotype
18973596 RGD
involved in olfactory nerve development IEP
IEP: Inferred from expression pattern
16262653 RGD
involved in oligodendrocyte differentiation IEP
IEP: Inferred from expression pattern
19236864 RGD
involved in positive regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
19112410 RGD
involved in positive regulation of glial cell differentiation IDA
IDA: Inferred from direct assay
19379790 RGD
involved in regulation of branching morphogenesis of a nerve IDA
IDA: Inferred from direct assay
20573699 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
18093178 RGD
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10231557 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24966370 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19386232 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
12853107 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
24966370 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15640160 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

reticulon-4

GLUT4 vesicle 20kDa protein

NI-220/250

foocen

glut4 vesicle 20 kDa protein

neurite outgrowth inhibitor

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12332 RTN4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12333 RTN4IP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12334 RTN4R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12335 RTN4RL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18682 Rtn4r Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18788 Rtn4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20640 Rtn4rl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25168 Rtn4r Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25277 Rtn4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27150 Rtn4rl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rtn4 NCBI NCBI:57142
Macaca fascicularis Rtn4 NCBI NCBI:101865007
Mus musculus Rtn4 NCBI NCBI:68585