2. Gene
  3. Fbn1 - fibrillin 1 Gene

Fbn1 - fibrillin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 83727 | Gene type: protein coding

About Fbn1

Summary

Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in cellular response to insulin-like growth factor stimulus; cellular response to transforming growth factor beta stimulus; and metanephros development. Located in collagen-containing extracellular matrix and extracellular region. Biomarker of glomerulonephritis; hypertension; liver cirrhosis; mesangial proliferative glomerulonephritis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including CREST syndrome; Weill-Marchesani syndrome; aortic disease (multiple); autosomal dominant isolated ectopia lentis 1; and bone disease (multiple). Orthologous to human FBN1 (fibrillin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fbn1 Products(1)

mRNA Protein Name
NM_031825.2 NP_114013.2 fibrillin-1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
17200203 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
11012893 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
9815129 RGD
involved in kidney development IMP
IMP: Inferred from mutant phenotype
9815129 RGD
involved in metanephros development IMP
IMP: Inferred from mutant phenotype
9815129 RGD
Cellular Component GO Annotation Evidence Reference Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
15849235 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
17200203 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibrillin-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04776 FBN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17804 Fbn1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24272 Fbn1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbn1 NCBI NCBI:2200
Mus musculus Fbn1 NCBI NCBI:14118