Rest - RE1-silencing transcription factor Gene

Rattus norvegicus

Also known as Nrsf

Gene ID: 83618 | Gene type: protein coding

About Rest

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cellular biosynthetic process; negative regulation of dense core granule biogenesis; and response to ischemia. Located in chromatin and nucleus. Part of transcription repressor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Rest Products(1)

mRNA	Protein	Name
NM_031788.2	NP_113976.2	RE1-silencing transcription factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9454838	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19342457	RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17130167	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17130167	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21284946	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10491605	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10490617	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	22371606	RGD
involved in modification of synaptic structure	IMP IMP: Inferred from mutant phenotype	22960932	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17130167	RGD
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11516394	RGD
involved in negative regulation of aldosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	19342457	RGD
involved in negative regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	21536750	RGD
involved in negative regulation of cortisol biosynthetic process	IMP IMP: Inferred from mutant phenotype	19342457	RGD
involved in negative regulation of dense core granule biogenesis	IMP IMP: Inferred from mutant phenotype	21536750	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25108103	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	12657670	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22960932	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	24841827	RGD
involved in positive regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	12657670	RGD
involved in response to ischemia	IDA IDA: Inferred from direct assay	22371606	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	12657670	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	11516394	RGD
located in nucleus	IDA IDA: Inferred from direct assay	7697725	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	10491605	RGD
part of transcription repressor complex	IDA IDA: Inferred from direct assay	17130167	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RE1-silencing transcription factor

neural-restrictive silencer factor

zinc finger transcription factor REST protein

Related Agents

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0069	Fludarabine		99.77%	Yes
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-70057	Safinamide	Inhibitor	99.89%	Yes
HY-70057A	Safinamide mesylate	Inhibitor	99.07%	Yes
HY-B1194	Tetramisole hydrochloride		99.93%	Unkown
HY-B0516	Articaine hydrochloride	Inhibitor	99.38%	Unkown
HY-A0083B	Methacholine bromide	Agonist	/	Unkown
HY-B0516A	Articaine	Inhibitor	/	Unkown
HY-B0516R	Articaine hydrochloride (Standard)	Inhibitor	/	Unkown
HY-B1194A	Tetramisole		/	Unkown
HY-B0069R	Fludarabine (Standard)		/	Unkown

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136833	X5050	Inhibitor	98.05%	Unkown
HY-12680	PRN694	Inhibitor	≥99.0%	Unkown
HY-136460	Calcium ionophore I		99.6%	Unkown
HY-W013712	GI-530159	Activator	99.27%	Unkown
HY-103178	MRE3008F20	Antagonist	99.70%	Unkown
HY-106667	DL 071IT	Inhibitor	98.81%	Unkown
HY-RS11853	REST Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-142682	SCP1-IN-1	Inhibitor	98.63%	Unkown
HY-142683	SCP1-IN-2	Inhibitor	98.77%	Unkown
HY-P10817A	Corza6 TFA	Inhibitor	/	Unkown
HY-103298	MNI-caged kainate		/	Unkown
HY-116790B	(±)-Penbutolol	Antagonist	/	Unkown
HY-125452	DiSBAC10		/	Unkown
HY-137618B	Rp-dGTPαS		/	Unkown
HY-149483	CVN417	Antagonist	/	Unkown
HY-159986	X-17	Inhibitor	/	Unkown
HY-161272	Nav1.8-IN-6	Inhibitor	/	Unkown
HY-162478	GR-28		/	Unkown
HY-70057S1	Safinamide-d4-1	Inhibitor	/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-P10817	Corza6	Inhibitor	/	Unkown
HY-P5152	Scorpion toxin Tf2	Activator	/	Unkown
HY-W328882	3-(2-Aminopropyl)phenol		/	Unkown
HY-152901	Chol-N3		/	Unkown
HY-70057S4	Safinamide-d5	Inhibitor	/	Unkown
HY-RS17141	Rest Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23588	Rest Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rest	NCBI	NCBI:5978
Macaca fascicularis	Rest	NCBI	NCBI:102116020
Mus musculus	Rest	NCBI	NCBI:19712

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