Pggt1b - protein geranylgeranyltransferase type I subunit beta Gene

Rattus norvegicus

Gene ID: 81746 | Gene type: protein coding

About Pggt1b

Summary

Enables heterocyclic compound binding activity. Contributes to several functions, including CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell population proliferation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Pggt1b Products(1)

mRNA	Protein	Name
NM_031082.2	NP_112344.1	geranylgeranyl transferase type-1 subunit beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to CAAX-protein geranylgeranyltransferase activity	IDA IDA: Inferred from direct assay	8089111	RGD
enables CAAX-protein geranylgeranyltransferase activity	IDA IDA: Inferred from direct assay	14609943	RGD
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	15248757	RGD
contributes to peptide binding	IDA IDA: Inferred from direct assay	9705207	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14609943	RGD
contributes to small molecule binding	IDA IDA: Inferred from direct assay	15248757	RGD
contributes to zinc ion binding	IDA IDA: Inferred from direct assay	15248757	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	14609943	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	9153192	RGD
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	10544242	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10544242	RGD
involved in protein geranylgeranylation	IDA IDA: Inferred from direct assay	14609943	RGD
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	9153192	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of CAAX-protein geranylgeranyltransferase complex	IDA IDA: Inferred from direct assay	14609943	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

geranylgeranyl transferase type-1 subunit beta

GGTase-I-beta	geranylgeranyl transferase type I subunit beta
geranylgeranyltransferase type 1 beta	geranylgeranyltransferase type I (GGTase-I)
protein geranylgeranyltransferase type 1 subunit beta	protein geranylgeranyltransferase type I, beta subuni

Pggt1b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pggt1b	P53610	Fnta	Rattus norvegicus	Q04631	Pull Down	18957540
Intra	Pggt1b	P53610	Fnta	Rattus norvegicus	Q04631	X-Ray Diffraction	15248757

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10383	PGGT1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21169	Pggt1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27686	Pggt1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pggt1b	NCBI	NCBI:5229

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