Actr3 - actin related protein 3 Gene

Rattus norvegicus

Also known as Arp3

Gene ID: 81732 | Gene type: protein coding

About Actr3

Summary

Enables ATPase binding activity and actin binding activity. Involved in several processes, including neurogenesis; positive regulation of cellular component organization; and positive regulation of protein localization to membrane. Located in several cellular components, including apical ectoplasmic specialization; basal ectoplasmic specialization; and concave side of sperm head. Part of apical tubulobulbar complex. Is active in glutamatergic synapse and postsynapse. Colocalizes with actin filament. Used to study focal segmental glomerulosclerosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Actr3 Products(1)

mRNA	Protein	Name
NM_031068.1	NP_112330.1	actin-related protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	23403943	RGD
enables actin binding	IDA IDA: Inferred from direct assay	20566646	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18064521	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Sertoli cell barrier remodeling	IEP IEP: Inferred from expression pattern	20534520	RGD
involved in astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23843614	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	10209028	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	21191089	RGD
involved in cellular response to pyrimidine ribonucleotide	IEP IEP: Inferred from expression pattern	22065602	RGD
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	22319661	RGD
involved in cellular response to trichostatin A	IEP IEP: Inferred from expression pattern	12445420	RGD
involved in cellular response to triterpenoid	IEP IEP: Inferred from expression pattern	20566646	RGD
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	22319661	RGD
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	19846719	RGD
involved in negative regulation of bleb assembly	IMP IMP: Inferred from mutant phenotype	22786929	RGD
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	18256280	RGD
involved in positive regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23843614	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	18430734	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	23441206	RGD
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	20566646	RGD
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	18256280	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	18256280	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18256280	RGD
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21844200	RGD
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	20739464	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	18430734	RGD
involved in postsynapse organization	IDA IDA: Inferred from direct assay	18430734	RGD
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	18430734	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	18430734	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18430734	RGD
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20739464	RGD
involved in regulation of myosin II filament organization	IMP IMP: Inferred from mutant phenotype	18256280	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19095743	RGD
involved in response to heparin	IEP IEP: Inferred from expression pattern	17488504	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	20534520	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	15147909	RGD
located in actin filament	IDA IDA: Inferred from direct assay	10209028	RGD
located in apical ectoplasmic specialization	IDA IDA: Inferred from direct assay	23546604	RGD
part of apical tubulobulbar complex	IDA IDA: Inferred from direct assay	22797892	RGD
located in basal ectoplasmic specialization	IDA IDA: Inferred from direct assay	23546604	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	17855387	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	22319661	RGD
located in concave side of sperm head	IDA IDA: Inferred from direct assay	22332112	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	18430734	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18430734	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18430734	RGD
located in hemidesmosome	IDA IDA: Inferred from direct assay	15093736	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	15252126	RGD
located in leading edge of lamellipodium	IDA IDA: Inferred from direct assay	17855387	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22319661	RGD
located in podosome	IDA IDA: Inferred from direct assay	15093736	RGD
located in podosome core	IDA IDA: Inferred from direct assay	24290759	RGD
is active in postsynapse	EXP EXP: Inferred from Experiment	15020595	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	15020595	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	18430734	RGD
located in ruffle	IDA IDA: Inferred from direct assay	10209028	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

actin-related protein 3

ARP3 actin related protein 3 homolog	actin-like protein 3
actin-related protein 3 homolog (yest)

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00231	ACTR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00232	ACTR3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19403	Actr3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25895	Actr3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Actr3	NCBI	NCBI:10096

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