2. Gene
  3. Dlat - dihydrolipoamide S-acetyltransferase Gene

Dlat - dihydrolipoamide S-acetyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81654 | Gene type: protein coding

About Dlat

Summary

Enables dihydrolipoyllysine-residue acetyltransferase activity. Involved in acetyl-CoA biosynthetic process from pyruvate and sleep. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dlat Products(1)

mRNA Protein Name
NM_031025.1 NP_112287.1 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables dihydrolipoyllysine-residue acetyltransferase activity IDA
IDA: Inferred from direct assay
7487891 RGD
Biological Process GO Annotation Evidence Reference Source
involved in acetyl-CoA biosynthetic process from pyruvate IDA
IDA: Inferred from direct assay
7487891 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
3571977 RGD
part of pyruvate dehydrogenase complex IDA
IDA: Inferred from direct assay
7487891 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

70 kDa mitochondrial autoantigen of primary biliary cirrhosis

E2

PBC

PDC-E2

PDCE2

dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

p

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03792 DLAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17105 Dlat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116330 Hyperforin / Unkown
HY-176305S Neurofilament, U-15N / Unkown
HY-RS23549 Dlat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlat NCBI NCBI:1737
Mus musculus Dlat NCBI NCBI:235339