ATIC - Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Gene

Rattus norvegicus

Gene ID: 81643 | Gene type: protein coding

About ATIC

Summary

Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in several processes, including animal organ development; folic acid-containing compound metabolic process; and nucleobase-containing small molecule metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]

ATIC Products(1)

mRNA	Protein	Name
NM_031014.2	NP_112276.2	bifunctional purine biosynthesis protein ATIC

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables IMP cyclohydrolase activity	IDA IDA: Inferred from direct assay	9332377	RGD
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IDA IDA: Inferred from direct assay	9332377	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	25687571	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' IMP biosynthetic process	IDA IDA: Inferred from direct assay	9332377	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	9332377	RGD
involved in brainstem development	IEP IEP: Inferred from expression pattern	7057182	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	7057182	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	7057182	RGD
involved in dihydrofolate metabolic process	IDA IDA: Inferred from direct assay	8948466	RGD
involved in tetrahydrofolate biosynthetic process	IDA IDA: Inferred from direct assay	7057182	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bifunctional purine biosynthesis protein ATIC

AICAR transformylase/inosine monophosphate cyclohydrolase	bifunctional purine biosynthesis protein PURH
bifunctional purine biosynthesis protein PURH-like

ATIC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Atic	O35567	P15127-PRO_0000016698	Rattus norvegicus	P15127-PRO_0000016698	Anti Bait CoIP	25687571

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0485	Liensinine Diperchlorate	Inhibitor	99.97%	Phase 2
HY-135238	(rel)-RSD 921	Agonist	/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990067	Evunzekibart	Inhibitor	97.02%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150252A	ATIC-IN-1 acetate	Inhibitor	99.96%	Unkown
HY-N1448	Vincetoxicoside B	Inhibitor	99.90%	Unkown
HY-29244	ATIC-IN-2	Inhibitor	≥98.0%	Unkown
HY-150252	ATIC-IN-1		99.69%	Unkown
HY-141324	Tetraethyl butane-1,4-diylbis(phosphoramidate)		/	Unkown
HY-E70121	Succinyl-CoA synthetase		/	Unkown
HY-RS01126	ATE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01156	ATIC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17124	Atic Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23569	Atic Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ATIC	NCBI	NCBI:471
Canis lupus familiaris	ATIC	NCBI
Mus musculus	ATIC	NCBI	NCBI:108147
Macaca mulatta	ATIC	NCBI	NCBI:694819

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